A graph-based research workspace and a terminal agent for scientific work. Two products that ship independently and pair through MCP.

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Get going in one command

Install the CLI: 
npx synsci
Or open the research workspace at thesis.syntheticsciences.ai. Both share a Synthetic Sciences account.

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Thesis

A graph-based research workspace. Hypotheses, experiments, sources, and decisions live as durable, branchable nodes. Ships an 86-tool MCP server for Cursor, Claude Code, Codex, and other agent hosts.
  • Introduction. What Thesis is for and how it works.
  • Quickstart. Sign in, create your first node, index a source, talk to the agent.
  • Web app tour. Every UI area explained.

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Thesis MCP

Connect Thesis to the agent host you already use. The setup helper writes the MCP config for every detected host in one command.

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Synsci CLI

A terminal agent for scientific work. The binary is synsc. Pick a research mode and the agent loads the right domain conventions, tools, and backends for the work.
  • Introduction. What synsc is and what each research mode covers.
  • Installation. npx synsci does the entire setup.
  • Quickstart. Connect, pick a mode, send your first prompt.

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Research modes

ModeFor
ResearchCross-disciplinary work, literature review, hypothesis generation, GPU compute orchestration
PhysicsSimulation, PDE solving, dynamical systems, symbolic regression
ChemistryDrug discovery, molecular design, ADMET, docking, structure prediction
BiologyBioinformatics, sequencing pipelines, single-cell analysis, structure prediction
FlywheelBuild a specialized LLM from your production data

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Common workflows

Start at the Thesis quickstart. Create a root node, index a paper or two, talk to the agent, stage an experiment when you’re ready. The web app at thesis.syntheticsciences.ai is enough. You don’t need any CLI.
Install with npx synsci, then run synsc web --mode <your-domain>. The bundled domain tools and credential sync mean you can start running scientific workflows in minutes. No Thesis account needed.
Set up both products. Connect them with synsc mcp add thesis --url https://thesis.syntheticsciences.ai/mcp-server. The agent stages experiments in Thesis while it runs the actual work in your repo. See Connect Synsci CLI to Thesis.
Use your existing IDE agent host. Run npx --yes @synsci/thesis setup to wire Thesis into the host’s MCP config. Your agent gets the 86 Thesis tools alongside its built-ins. Synsci CLI is optional.

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Account and billing

Both products share a Synthetic Sciences account. Thesis web app and MCP server use your account for project access. Synsci CLI dashboard at cli.syntheticsciences.ai issues Bearer tokens, holds synced credentials, and tracks credit usage. Plans and credits are scoped per product. Subscribe to either or both. Visit your account page for plan details.